OFFERING: The first independent edition of the pioneering work on diabetes management, summarizing fifteen years of clinical studies and describing the first effective treatment for adult onset (Type 2 diabetes) since Avicenna. Bouchardat's treatment advocates patient education with a self-monitoring regimen of glucose urinalysis (using the Trommer test), vigorous exercise and a nutritious, sustainable low carbohydrate diet. Virtually unobtainable for decades, the text with professional conservation to 24 leaves is offered in the original printed lemon paper wrappers, bound into matching buff cloth boards. RARITY: Rare. Because of its exceptional rarity, standard bibliographical works in English don't record the work. A worldwide catalog search finds 12 institution holdings, including Yale, Stanford and the University of Chicago. It is an extract from Des Mémoires de L'Académie Nationale de Médicine, vol. 16, pp. 69-212, published by Libraire de L'Académie Nationale de Médicine. CONDITION: Good. Pages: tears expertly repaired to fragile, thin paper, primarily in top and bottom margins, including the half-title and title pages; soiling to outer pages, some pages with bottom corner wear, a few with trace fore-edge soiling, pp. 52-55 with tiny scattered spots and a margin stain. / Wrappers: bottom corner crease, chipped edges, some soiling. / Boards: About Fine. / Binding: Excellent. PAGINATION: Complete; 144 pages, no illustration, verso of half-title page with some of the author's prior publications. Complete title: Du diabete sucre, ou, glucosurie: son traitement hygienique. Introduction, pp. 1-2; Section I, Pratiques sur la Glucosurie, pp. 3-62; Section II, Se Repportant a L'Etiologie de la Glucosuries, pp. 63-101; Section III, Du Traitement de la Glucosurie, pp. 102-126; Section IV, Partie Historique et Critique, pp. 127-140; List of selected publications based on original research, p. 141; Note sur L'Utilisation, Du Sucre D'Inuline ou du Sucre Lévogyre par Les Glucosuriques, pp 142-144. SIZE: Boards: 283 x 229 mm / Wrappers: 280 x 225 mm. Apollinaire BOUCHARDAT [1806-1886]: was the first to develop a clinically proven treatment for Type 2 Diabetes that effectively reduced glucose levels in the blood. Until the discovery of insulin in 1921 and the later clinical work of Elliot P. Joslin, Bouchardat was the clinician of reference. "The originator of the field of diabetology" [Karamanou et al, Hormones, 12 (2), p. 297], he brought hope to diabetics, demonstrating how this devastating disease, until then, untreatable, could be managed, allowing them to live a normal lifespan. Trained as a pharmacist and nutritionist, he made contributions in many scientific disciplines, studying organic chemistry at the Ecole de Pharmacie de Paris with advanced study at the Muséum d'Histoire Naturelle. From 1835 he was chief pharmacist at the Hôtel Dieu, Paris, and from the 1850s, Professor of Public Health on their faculty. He "observed the histological changes of the pancreas in diabetes" and "carried out numerous experiments to study in depth the digestion of starches" [ibid]. Bouchardat began his clinical diabetes studies in 1835, measuring glycosuria with the Biot polarimeter and applying its daily measurement to patient treatment, insisting "it was the compass". [Joslin, Apollinaire Bouchardat. Diabetes 1: 490-491] In 1841, he introduced gluten bread (starch removed) as part of his recommended diet for diabetic patients. After 1871, based on his observations of the 1870 German siege of Paris, he advocated a low intake diet with the minimum calories required for sustenance. In 1875, he published his definitive text, "De La Glycosurie Ou Diabète Sucre". REFERENCE: Karamanou et al, Apollinaire Bouchardat: founder of modern Diabetology, Hormones 2014, 13(2): 296-300. Joslin et al, Joslin's Diabetes Mellitus; "Bouchardat's pioneering and meticulous long-term studies on human diabetes", p. 3. ADDITIONAL IMAGES: by request.