OFFERING: The first independent edition of the landmark text on the therapeutic treatment of diabetes, in the original, printed lemon paper wrappers, later bound into modern buff cloth boards with professional conservation to 24 leaves. The work details fifteen years of clinical studies and describes the first effective treatment for Type 2 (adult onset) diabetes since Avicenna, based on meticulous attention to glucose levels in the patient's urine, a regimen of regular physical exercise and a nutritious low carbohydrate diet. RARITY: Exceedingly Rare. A worldwide catalog search finds 9 institution holdings, including Yale, Stanford and the University of Chicago. The work has been nearly unobtainable for decades. EDITION NOTE: Libraire de L'Académie Nationale de Médicine, French, printed from type by L. Martinet, Paris, extracted from Volume 16, pp. 69-212 of Des Mémoires de L'Académie Nationale de Médicine. CONDITION: Pages: tears to thin paper expertly repaired, primarily to top and bottom margins, including half-title page and title page; some pages with bottom corner wear: soiling to extremities (not endpapers), a few pages with trace fore-edge soiling, pp. 52-55 with tiny scattered margin spots and a margin stain. / Wrappers: edges chipped, a bottom corner crease, some soiling. / Boards: About Fine. / Binding: Excellent. PAGINATION: Complete; text with footnotes, no illustration: [2 leaves], half-title page, (verso with 15 author publications), title page, verso blank + 144 pages. Introduction, pp. 1-2; Section I, Pratiques sur la Glucosurie, pp. 3-62; Section II, Se Repportant a L'Etiologie de la Glucosuries, pp. 63-101; Section III, Du Traitement de la Glucosurie, pp. 102-126; Section IV, Partie Historique et Critique, pp. 127-140; List of selected publications based on original research, p. 141; Note sur L'Utilisation, Du Sucre D'Inuline ou du Sucre Lévogyre par Les Glucosuriques, pp 142-144. SIZE: Wrappers: 280 x 225 mm / Boards: 283 x 229 mm. FORMAT: Publisher's printed lemon paper wrappers with beveled corners, title on the upper side, publisher's advertisements on the lower side, bound in buff cloth boards with a mounted cream paper title slip on the upper side, sewn with custom endpapers with matching rounded corners. Apollinaire BOUCHARDAT [1806-1886]: French pharmacist and nutritionist, trained in organic chemistry at the Ecole de Pharmacie de Paris with advanced study at the Muséum d'Histoire Naturelle; chief pharmacist at the Hôtel Dieu, Paris, from 1835, and from the 1850's, Professor of Public Health on their faculty; early important study of fermentation, author of the influential, encyclopedic "Nouveau Formulaire Magistral"; began clinical studies of diabetes in 1835. After years of research and patient treatment, he was the clinician of reference on diabetes until Elliot P. Joslin published his findings. Bouchardat was the first to develop a clinically proven treatment for Type 2 Diabetes that effectively reduced glucose levels. His dietetic therapy included daily self-testing by patients of the glucose levels in their urine using the Trommer test, a regimen of physical exercise, and a low carbohydrate diet that unlike the recommended diet of fatty meats prescribed by John Rollo ("An Account of Two Cases of the Diabetes Mellitus") was nutritionally balanced, palatable, and sustainable. After 1871, based on his observations of the 1870 German siege of Paris, he advocated a low intake diet with the minimum calories required for sustenance and in 1875 he published his definitive text, "De La Glycosurie Ou Diabète Sucre", which included his observations on lesions in the pancreas. REFERENCE: Joslin et al, Joslin's Diabetes Mellitus, p. 3, authors praise, "Bouchardat's pioneering and "meticulous long-term studies on human diabetes". Standard bibliographical works record only the 1875 book: Garrison-Morton 3940; Hirsch I/646-47. ADDITIONAL IMAGES: by request.