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DNA Vaccines
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DNA Vaccines Hardcover - 1999 - 1st Edition

by Douglas B. Lowrie (Editor); Robert Whalen (Editor)


From the publisher

The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet "naked DNA," could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications. In a separate and important line of experimentation, Tang, De Vit, and Johnston announced in 1992 that it was indeed possible to obtain humoral immune responses against proteins encoded by DNA delivered to the skin by a biolistic device, which has colloquially become known as the "gene gun. " The year 1993 saw the publication of further improvements in the me- ods of naked DNA delivery and, above all, the first demonstrations by several groups of the induction of humoral and cytotoxic immune responses to viral antigens expressed from injected plasmid DNA. In some cases, protection against challenge with the pathogen was obtained. The latter result was - questionably the touchstone of a method of vaccination worthy of the name.

From the rear cover

In DNA Vaccines: Methods and Protocols, state-of-the-art review articles by leading experts summarize how to develop and employ the highly promising new DNA vaccines, what clinical results can be expected from their use, and what is known about how they work. Key topics range from vaccine design and construction to preparation and delivery methods, including the use of classical adjuvants, "genetic adjuvants," and the immunostimulatory properties of DNA and selected oligonucleotide sequences. Several contributors provide strategic ideas on antigen engineering and describe the particularly novel applications of DNA vaccine methodology that have recently emerged. In addition, there is a discussion of dendritic cells and antigen-presenting cells, the understanding of whose actions holds great promise for modulating the immune response, and thus for treating disease. Cutting-edge and comprehensive, DNA Vaccines: Methods and Protocols provides a broad panorama of the methods and thinking from which the vaccines of tomorrow will evolve, and so constitutes an invaluable sourcebook for both experts developing new applications and newcomers who want to gain mastery of the techniques and problems involved.

Details

  • Title DNA Vaccines
  • Author Douglas B. Lowrie (Editor); Robert Whalen (Editor)
  • Binding Hardcover
  • Edition number 1st
  • Edition 1
  • Pages 529
  • Volumes 1
  • Language ENG
  • Publisher Humana
  • Date 1999-09-23
  • ISBN 9780896035805 / 0896035808
  • Weight 1.91 lbs (0.87 kg)
  • Dimensions 9.32 x 6.39 x 1.31 in (23.67 x 16.23 x 3.33 cm)
  • Library of Congress subjects DNA vaccines - Research - Methodology
  • Library of Congress Catalog Number 98-55325
  • Dewey Decimal Code 615.372
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DNA Vaccines: Methods and Protocols (Methods in Molecular Medicine, 29)
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DNA Vaccines: Methods and Protocols (Methods in Molecular Medicine, 29)

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DNA Vaccines: Methods and Protocols
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DNA Vaccines: Methods and Protocols

by Lowrie, D, B. and Whalen, R, G. (eds)

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DNA Vaccines: Methods and Protocols
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DNA Vaccines: Methods and Protocols

by Lowrie, D, B. and Whalen, R, G. (eds)

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Humana, 2000. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,950grams, ISBN:9780896035805
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DNA Vaccines: Methods and Protocols
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DNA Vaccines: Methods and Protocols

by Lowrie, D, B. and Whalen, R, G. (eds)

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DNA Vaccines : Methods and Protocols
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DNA Vaccines : Methods and Protocols

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DNA Vaccines: Methods and Protocols (Methods in Molecular Medicine, 29)
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DNA Vaccines: Methods and Protocols (Methods in Molecular Medicine, 29)

by Lowrie, Douglas B. [Editor]; Whalen, Robert [Editor];

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