Alpha2adrenergic Receptors Hardcover - 1997 - 1st Edition

First line

The initial identification, of the 2-adrenoceptor was coupled to the discovery of the prejunctional autoreceptor on adrenergic nerve terminals which participates in the negative feedback system controlling norepinephrine release in response to sympathetic nerve activation (for details of the history see Starke, 1977).

From the rear cover

This book undertakes to cover all angles of current research in (actual symbol not reproducible) receptors, each chapter being written by a leader in the field. Starting with an excellent overview of the subject, it provides insights into ligand binding and the effects of site-directed mutagenesis; the transfer of the signal through the G-protein to various effectors and the internal cellular response; receptor trafficking; and the therapeutic implications of the receptors, with the effects of agonists and antagonists. The scope of this volume makes it an indispensable guide for researchers working on any feature of (actual symbol not reproducible) receptors. It will also prove valuable to anyone with an interest in the structure and function of G-protein coupled receptors and the mechanisms by which they direct the response of the cell to multiple types of external stimuli.