AUTOGRAPH NOTE SIGNED by Sir Augustus d'Este, the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made by d'Este, Sir Augustus Frederick (1794-1848) - 1814.

May 2nd, 1814.. 1814.. Good. SIR AUGUSTUS D'ESTE WAS THE EARLIEST RECORDED PERSON FOR WHOM A DEFINITE DIAGNOSIS OF MULTIPLE SCLEROSIS (MS) CAN BE MADE - sc Approximately 20 words penned on a 6-1/8 inch high by 4-1/4 inch wide sheet of watermarked paper. "I have the honor my dear Sir of subscribing myself...." Signed "Augustus Frederick de Este". Folded horizontally and vertically. There are remnants of gray scrapbook paper mounted to the verso of the left edge of the sheet and the corners have been clipped. Good. <p>The grandson of George III and son of the Duke of Sussex, Sir Augustus Frederick d'Este (1794-1848) was active in the Aborigines Protection Society. He assisted the Mississauga missionary Peter Jones who argued for the giving Native Americans title to their lands in Upper Canada. His manuscript diaries recorded the onset of the symptoms of multiple sclerosis which began at the age of 28 and afflicted him for the next 22 years. Sir Augustus d'Este is the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made.