Braf Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery Hardcover - 2014
by Ryan J. Sullivan (Editor)
From the rear cover
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
Details
- Title Braf Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery
- Author Ryan J. Sullivan (Editor)
- Binding Hardcover
- Pages 204
- Volumes 1
- Language ENG
- Publisher Humana
- Date 2014-11-25
- Illustrated Yes
- ISBN 9781493921423 / 1493921428
- Weight 1.05 lbs (0.48 kg)
- Dimensions 9.21 x 6.14 x 0.5 in (23.39 x 15.60 x 1.27 cm)
-
Themes
- Aspects (Academic): Medical/Medicine Aspects
- Library of Congress subjects Melanoma, Protein Kinase Inhibitors - therapeutic use
- Library of Congress Catalog Number 2014955080
- Dewey Decimal Code 616.994
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BRAF Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery (Cancer Drug Discovery and Development, 82)
by Ryan J. Sullivan (Editor)
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BRAF Targets in Melanoma : Biological Mechanisms, Resistance, and Drug Discovery
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BRAF Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery (Cancer Drug Discovery and Development)
by Sullivan, Ryan J. [Editor]
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