Principles of Nucleic Acid Structure

Paperback / softback. New. A unique and practical resource, Principles of Nucleic Acid Structure, Second Edition, continues to provide the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical terms used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). Features include coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. There is extensive discussion on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative and comprehensive up-to-date information on all aspects of nucleic acid structure, from basic first principles through to details of recent research results in the field.