The p53 Tumor Suppressor Pathway and Cancer (Protein Reviews, Vol. 2) by Zambetti, Gerard P. [Editor] - 2006-01-11

Springer, 2006-01-11. Hardcover. Very Good. 2006 Springer Science Business Media, Inc. (New York), 6 1/4 x 9 1/2 inches tall pictorial hardcover, no dust jacket (as issued), illustrated with color graphs and charts, x, 246 pp. Very slight rubbing to covers. Otherwise, a very good to near fine copy - clean, bright and unmarked. ~SP05~ [2.0P] A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it significantly underrepresents how often the p53 pathway is targeted during tumorigenesis. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. Coontents: The p53 Network -- The Three-Dimensional Structure of p53 -- Transcriptional Activation by p53: Mechanisms and Targeted Genes -- Transcriptional Repression by the p53 Tumor Suppressor Protein -- Posttranslational Modifications of p53: Upstream Signaling Pathways -- p53 in Human Cancer ? Somatic and Inherited Mutations and Mutation-independent Mechanisms -- MDM2 and MDMX Regulators of p53 Activity -- p53 Family Members: p63 and p73 -- The Oncogenic Activity of p53 Mutants -- Therapeutic Strategies Based on Pharmacological Modulation of p53 Pathway.