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Isoquinolines and Beta-Carbolines as Neurotoxins and Neuroprotectants: New Vistas in Parkinson's Disease Therapy Hardcover - 2011 - 2012th Edition
by Lucyna Antkiewicz-Michaluk (Editor); Hans Rommelspacher (Editor)
From the rear cover
This book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties. Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease.
The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Perspectives In Parkinson's Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson's disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): BCs and TIQs. These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role asneuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.
Details
- Title Isoquinolines and Beta-Carbolines as Neurotoxins and Neuroprotectants: New Vistas in Parkinson's Disease Therapy
- Author Lucyna Antkiewicz-Michaluk (Editor); Hans Rommelspacher (Editor)
- Binding Hardcover
- Edition number 2012th
- Edition 2012
- Pages 178
- Volumes 1
- Language ENG
- Publisher Springer
- Date 2011-12-06
- Features Bibliography, Index
- ISBN 9781461415411 / 1461415411
- Weight 0.85 lbs (0.39 kg)
- Dimensions 9.2 x 6.3 x 0.6 in (23.37 x 16.00 x 1.52 cm)
- Library of Congress subjects Neurochemistry, Parkinson Disease
- Library of Congress Catalog Number 2011942264
- Dewey Decimal Code 616.833
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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants: New Vistas In Parkinson's Disease Therapy (Current Topics in Neurotoxicity, 1)
by Antkiewicz-Michaluk, Lucyna and Rommelspacher, Hans
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Isoquinolines and Beta-Carbolines As Neurotoxins and Neuroprotectants: New Vistas in Parkinson's Disease Therapy
by Antkiewicz-michaluk, Lucyna (Editor)/ Rommelspacher, Hans (Editor)
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- Hardcover
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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants : New Vistas In Parkinson's Disease Therapy
by Lucyna Antkiewicz-Michaluk
- New
- Hardcover
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- Hardcover
- ISBN 10 / ISBN 13
- 9781461415411 / 1461415411
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