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Endocrine Fgfs and Klothos
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Endocrine Fgfs and Klothos Hardcover - 2012 - 2012th Edition

by Makoto Kuro-O (Editor)


From the publisher

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Details

  • Title Endocrine Fgfs and Klothos
  • Author Makoto Kuro-O (Editor)
  • Binding Hardcover
  • Edition number 2012th
  • Edition 2012
  • Pages 210
  • Volumes 1
  • Language ENG
  • Publisher Springer
  • Date 2012-01-11
  • Illustrated Yes
  • ISBN 9781461408864 / 1461408865
  • Weight 1.4 lbs (0.64 kg)
  • Dimensions 10.3 x 7.1 x 0.7 in (26.16 x 18.03 x 1.78 cm)
  • Themes
    • Aspects (Academic): Science/Technology Aspects
  • Library of Congress subjects Fibroblast Growth Factors - metabolism, Endocrine System - metabolism
  • Library of Congress Catalog Number 2011026182
  • Dewey Decimal Code 573.4

About the author

MAKOTO KURO-O is an Associate Professor in the Pathology Department at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern). He also has an appointment to the Pak Center for Mineral Metabolism and the Simmons Comprehensive Cancer Center in UT Southwestern. He received his MD and PhD from the University of Tokyo, Japan. His major research interests include molecular mechanisms of aging and age-related diseases with special reference to chronic kidney disease. He is a member of the American Society of Nephrology (ASN).

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Endocrine FGFs and Klothos (Advances in Experimental Medicine and Biology, 728)
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Endocrine FGFs and Klothos (Advances in Experimental Medicine and Biology, 728)

by Makoto Kuro-o

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Endocrine FGFs and Klothos: 728 (Advances in Experimental Medicine and Biology)
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Endocrine FGFs and Klothos: 728 (Advances in Experimental Medicine and Biology)

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Endocrine FGFs and Klothos: Vol 728
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Endocrine FGFs and Klothos: Vol 728

by Kuro-o, Makoto (Editor)

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